1) purely personal pref. I buy mode 2 (throttle on left I think) because I use the ratchet for setting the gun elevation on my tank destroyers (self centering would point the gun at the sky).
2) throttle is the one that does not self center. You can ask horizon UK for a kit to fix that - see Mike B's thread (I need to get some more myself...)
3) Yes, you can program multiple receivers into the memory and switch control between them at the touch of a button. I haven't had any trouble using mine with DBCRC2HL's or 3rd party ESC's. Hopefully it will also talk to that El-Mod Tiger gathering dust at your place
4) if you were planning on getting it for just a DBCRC2HL equiped tank, a cheaper option could be the Dx5E - tho it doesn't have the model memory function, so is less useful for heli's and planes.
I'll have a right old mixture at Cobbo, so you can take a look there
